OSX-CRE directed ablation of site-1 protease in mice results in kyphosis and scoliosis
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چکیده
منابع مشابه
Relationship between Backpack Weight and Prevalence of Lordosis, Kyphosis, Scoliosis and Dropped Shoulders in Elementary Students
Background Carrying heavy backpacks by school students at growth age can cause irreversible physical harms. This study aimed to investigate the relationship between backpack weight and the incidence of lordosis, kyphosis, scoliosis, and dropped shoulders in elementary school students. Materials and Methods This descriptive-analytical study was conducted in 2015 in Abadan, Iran, and 383 elementa...
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15 صفحه اولCartilage-Specific Ablation of Site-1 Protease in Mice Results in the Endoplasmic Reticulum Entrapment of Type IIB Procollagen and Down-Regulation of Cholesterol and Lipid Homeostasis
The proprotein convertase site-1 protease (S1P) converts latent ER-membrane bound transcription factors SREBPs and ATF6 to their active forms. SREBPs are involved in cholesterol and fatty acid homeostasis whereas ATF6 is involved in unfolded protein response pathways (UPR). Cartilage-specific ablation of S1P in mice (S1Pcko) results in abnormal cartilage devoid of type II collagen protein (Col ...
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Osterix (Osx or Sp7) is a zinc-finger-family transcriptional factor essential for osteoblast differentiation in mammals. The Osx-Cre mouse line (also known as Osx1-GFP::Cre) expresses GFP::Cre fusion protein from a BAC transgene containing the Osx regulatory sequence. The mouse strain was initially characterized during embryogenesis, and found to target mainly osteoblast-lineage cells. Because ...
متن کاملTie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice.
Tissue-specific gene inactivation using the Cre-loxP system has become an important tool to unravel functions of genes when the conventional null mutation is lethal. We report here the generation of a transgenic mouse line expressing Cre recombinase in endothelial cells. In order to avoid the production and screening of multiple transgenic lines we used embryonic stem cell and embryoid body tec...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2014
ISSN: 1063-4584
DOI: 10.1016/j.joca.2014.02.245